A randomized comparison between rasburicase and allopurinol in children
نویسندگان
چکیده
Leonard Johnson, Conrad Tou, Elizabeth Harvey, Erin Morris and Mitchell S. Cairo Stanton C. Goldman, John S. Holcenberg, Jerry Z. Finklestein, Raymond Hutchinson, Susan Kreissman, F. December 1998. the American Society of Hematology Conference in Miami Beach, FL, with lymphoma or leukemia at high risk for tumor lysis : Presented in part at A randomized comparison between rasburicase and allopurinol in children
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis
Standard therapy in the United States for malignancy-associated hyperuricemia consists of hydration, alkalinization, and allopurinol. Urate oxidase catalyzes the enzymatic oxidation of uric acid to a 5 times increased urine soluble product, allantoin. Rasburicase is a new recombinant form of urate oxidase available for clinical evaluation. This multicenter randomized trial compared allopurinol ...
متن کاملA randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis.
Standard therapy in the United States for malignancy-associated hyperuricemia consists of hydration, alkalinization, and allopurinol. Urate oxidase catalyzes the enzymatic oxidation of uric acid to a 5 times increased urine soluble product, allantoin. Rasburicase is a new recombinant form of urate oxidase available for clinical evaluation. This multicenter randomized trial compared allopurinol ...
متن کاملEffects of Recombinant Urate Oxidase (Rasburicase) and Allopurinol for Prophylaxis and Treatment of Hyperuricemia in Patients with Leukemia and Lymphoma
Background: Efficacy of rasburicase in pediatric patients with leukemia and lymphoma is proved. This study aims toweigh efficacy and safety of rasburicase versus more conventional therapy, allopurinol, and to compare their safetyand properties in tumor lysis syndrome (TLS) of leukemia and lymphoma patients.Materials and Methods: The study was done with a retrospective cohort design. Patients we...
متن کاملاثر راسبوریکیس وآلوپورینول در پیشگیری و درمان بیماران مبتلا به هیپراوریسمی ناشی از سندروم لیز تومور در کودکان مبتلا به لوسمی و لنفوم در بیمارستان کودکان حضرت علی اصغر(ع): مطالعه کوهورت
Background: Tumor Lysis Syndrome (TLS) is the release of intracellular material into blood stream by itself or due to anticancer cytolytic therapies. Hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia are the main metabolic disorders of TLS. In order to treat and prevent hyperuricemia in TLS, we used Allopurinol and a new drug- Rasburicase. The aim of this study was to compare ...
متن کاملهیپراوریسمی در کودکان مبتلا به لنفوم و لوسمی و نقش درمان پروفیلاکتیک
Background: Hyperuricemia is one of the oncologic emergency that occurs most often in patients with hematologic disorders particularly leukemia and high-grade lymphoma. This study was conducted in order to determine the prevalence of hyperuricemia with respect to prophylactic treatment (in particular allopurinol) in patients with lymphoproliferative disease in the pediatric hematologic ward of ...
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